Full Study Name

Childhood Overgrowth Study (COG) study

Lead Site

Institute of Cancer Research

Local Principal Investigator

Prof Jill Clayton-Smith

Study Status


Main Aims

To clarify the clinical phenotypes associated with human overgrowth and the molecular abnormalities underlying them

Inclusion Criteria

1)         Any individual with overgrowth (defined as height and/or head circumference ≥ 2 standard deviations above mean) in association with at least one additional clinical feature such as:

  • Learning disability
  • Congenital abnormality
  • Skeletal abnormality
  • Neurological abnormality
  • Tumour

2)  Any individual with asymmetric growth.

We recruit families through Clinical Genetics departments as this ensures that full informed consent is obtained and provides an appropriate infrastructure for feedback of any research results.

Exclusion Criteria

None listed

Open Sites

Lead Site: Institute of Cancer Research. St George’s University Hospitals NHS Foundation Trust, Belfast health & social care trust, Great Ormond Street hospital for children NHS Foundation Trust, Cardiff & vale university lhb, University Hospital Southampton NHS Foundation Trust, University Hospitals Bristol NHS Foundation Trust, North West London hospitals NHS Trust, Guy’s and St Thomas’ NHS Foundation Trust,  Manchester University NHS Foundation Trust, NHS Greater Glasgow and Clyde, Oxford University Hospitals NHS Foundation Trust, Newcastle upon Tyne Hospitals NHS Foundation Trust, Nottingham University Hospitals NHS Trust, Cambridge University Hospitals NHS Foundation Trust, Sheffield Children’s NHS Foundation Trust, Birmingham women’s NHS Foundation Trust, Royal Devon and Exeter NHS Foundation Trust, Oxford University Hospitals NHS Foundation Trust,  NHS Grampian, Liverpool women’s NHS Foundation Trust, Leeds teaching hospitals NHS Trust, Peterborough and Stamford hospitals NHS Foundation Trust, London North West healthcare NHS Trust, NHS Tayside, University hospitals Bristol NHS Foundation Trust, Royal Marsden NHS Foundation Trust, Leeds teaching hospitals NHS Trust, NHS Grampian, NHS Lothian, Alder Hey children’s NHS Foundation Trust, Liverpool PCT, South Tees hospitals NHS Foundation Trust

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