Professor Jill Clayton-Smith MBChB FRCP MD Consultant Clinical Geneticist and Honorary Professor in Medical Genetics

GMC Registered (2613811)


Professor Jill Clayton-Smith graduated from the Victoria University of Manchester Medical School in 1982 with MBChB Hons and trained in cardiothoracic medicine, obstetrics and paediatrics, obtaining MRCP in 1985. After specialising in paediatrics, she entered Clinical Genetics in 1986 and undertook an MD at the Institute of Child Health London in 1989-1991. Professor Clayton-Smith completed her training in genetics in Manchester and took up a consultant post in 1994. She became a Fellow of the Royal College of Physicians in 1999 and an honrary Professor of Medical Genetics in 2006.

Professor Clayton-Smith's research interests include identifying the genetic basis and natural history of intellectual disability syndromes. She has a longstanding research interest in the effects on the fetus of taking antiepileptic drugs in pregnancy and has undertaken several studies in the area of cleft lip and palate.

Her clinical specialist interests are in Angelman Syndrome, a neurodevelopmental disorder, and related conditions. She has been involved in this field for over 25 years. Professor Clayton-Smith also has an interest in developmental eye disorders and in rare syndrome diagnosis in general.


General syndrome diagnosis clinics at St Mary’s Hospital twice monthly, at Royal Preston Hospital every two months and at Rochdale Infirmary every two months.
Genetic Eye clinic monthly (first Friday) and every two months (Tuesday).
Multidisciplinary Angelman Syndrome clinic three monthly at St Mary’s Hospital.
Annual joint clinic with community paediatrician at Melland School.