INSIGNIA – Exploring the biological processes underlying mutational signatures identified in patients with inherited disorders and in patients exposed to mutagensLocal Principal Investigator
Professor Jill Clayton-SmithStudy Status
The purpose of this study is to understand how and why damage accumulates in DNA.
Almost all the cells in the body contain a copy of the human genetic code (or DNA). This DNA is constantly damaged and this can lead to errors in the genetic code. Usually, these errors are corrected by a person’s DNA repair toolkit that exists in cells. Occasionally, some errors are missed or become permanent changes. These changes are called mutations.
We are studying mutations that have built up in cells to understand how and why they cause health problems like cancer, brain diseases and aging.Inclusion Criteria
Patients with the following:
Those individuals not matching the above inclusion criteria.Open Sites
Aberdeen, Belfast, Birmingham, Bristol, Cardiff, Cambridge, Dundee, Edinburgh, Exeter, GOSH, Glasgow, Guy’s, Leicester, Leeds, Liverpool, Newcastle, Nottingham, North West London, Oxford, Sheffield, Southampton, St Marys Hospital -Manchester, St George’s, Royal MarsdenFor more information click here