Full Study Name

EMBRACE: Epidemiological Study of BRCA1 and BRCA2 Mutation Carriers

Lead Site


Local Principal Investigator

Professor Gareth Evans

Study Status


Main Aims

The aims of this study are two-fold:

  • to define a cohort of BRCA1 and BRCA2 mutation carriers identified throughout the U.K. and Eire, who can be followed prospectively to determine cancer risks and to examine the efficacy of different interventions;
  • to obtain simple epidemiological information, by questionnaire, on affected and unaffected gene carriers, in order to determine lifestyle factors which may modify risk.
  • These data will be collected on a national basis but with the aim of combining them into an international study.
Inclusion Criteria
  • known carriers of a BRCA1/2 mutation  (affected or unaffected)
  • are undergoing, have undergone or may potentially undergo testing for BRCA1 or BRCA2 mutations (affected or unaffected).
  • Both males and female are eligible as are women who have had prophylactic bilateral mastectomies or oophorectomies.
Exclusion Criteria
  • under 18 years of age;
  • those who lack mental capacity and would be unable to give informed consent;
  • those who at the local investigators discretion are not thought appropriate e.g. recent family bereavement, late stages of breast cancer, etc.
Open Sites

UK Coordinating Centre – Cambridge.  The Royal Marsden Hospital (Surrey), St Bartholomew’s Hospital Bristol, Belfast City Hospital, Belfast, Ysbyty Glan Clwyd, Birmingham Women’s Hospital, Addenbrooke’s Hospital Cambridge, University Hospital Of Wales, St Mary’s Hospital Manchester, Great Ormond Street Hospital Central London, Guy’s Hospital London, St James’s University Hospital, Northwick Park Hospital Harrow, Aberdeen Royal Infirmary Aberdeen, Western General Hospital Edinburgh, Nottingham University Hospitals Nhs Trust – City Campus, Churchill Hospital Oxford, Royal Devon & Exeter Hospital (Wonford), Southend Hospital Southend-On-Sea, St George’s Hospital (Tooting), The Newcastle Upon Tyne Hospitals Nhs Foundation Trust, Princess Anne Hospital, Leicester Royal Infirmary, Singleton Hospital Cwmrhydyceirw, Chapel Allerton Hospital Leeds, Liverpool Womens Hospital, Royal Hospital For Sick Children (Glasgow), Southern General Hospital Glasgow, Raigmore Hospital Inverness, Sheffield Children’s Hospital, St Michael’s Hospital Bristol

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