Full Study Name

BOCS – Breast and Ovarian Cancer Susceptibility

Lead Site

The Royal Marsden

Chief Investigator

Prof. Nazeen Rahman

Local Principal Investigator

Dr Fiona Lalloo

Study Status


Main Aims
  • Collection and curation of samples from breast and/or ovarian cancer families.
  • Identification of breast and/or ovarian cancer susceptibility genes using next-generation sequencing approaches.
  • Characterisation of the prevalence, penetrance, phenotype and interactions of mutations in breast and/or cancer susceptibility genes.
  • Any individual with ovarian cancer and at least one relative with breast or ovarian cancer
Inclusion Criteria
  • Any individual with bilateral breast cancer
  • Any individual with both breast and ovarian cancer
  • Any individual with male breast cancer
  • Any individual with ovarian cancer and at least one relative with breast or ovarian
Exclusion Criteria

None specified

Open Sites

The Royal Marsden, Belfast City Hospital, Ysbyty Glan Clwyd, Birmingham Women’s Hospital, Addenbrookes, University Hospital of Wales, Manchester University NHS Foundation Trust, Countess of Chester Hospital, Great Ormond Street, Guy’s Hospital, Aberdeen Royal Infirmary, Western General Hospital (Edinburgh), Ninewells Hospital (Dundee), Cumberland Infirmary, North West London Hospitals NHS Trust, Nottingham University Hospital NHS Trust, Churchill Hospital (Oxford), North Manchester General Hospital, Derriford Hospital (Plymouth), Royal Cornwall Hospital, Royal Devon and Exeter Hospital, St George’s Hospital (London), Musgrove Park Hospital (Taunton), Newcastle Upon Tyne Hospital NHS Foundation Trust, Princess Anne Hospital, Leicester Royal Infirmary, Singleton Hospital (Swansea), Chapel Allerton Hospital (Leeds), Liverpool Women’s Hospital, Royal Hospital for Sick Children (Glasgow), Southern General Hospital (Glasgow), Raigmore Hospital (Inverness), Sheffield Children’s Hospital, St Michael’s Hospital (Bristol), Alder Hey Children’s NHS Foundation Trust (Liverpool), Northern Centre for Cancer Care, Totnes Hospital (Ashburton), Newton Abbot Community Hospital.