In about 2-5% of couples with a history of recurrent miscarriage, one partner carries a balanced chromosome rearrangement which confers an increased risk of miscarriage or live births with an unbalanced chromosome rearrangement. For couples ascertained following recurrent miscarriage, the risk of chromosomally unbalanced pregnancies surviving to term is low and therefore routine karyotyping of these couples is not indicated.
From April 1st 2014, in accordance with the Royal College of Obstetricians and Gynaecologists guidelines, parental blood samples are no longer accepted from couples with isolated or recurrent pregnancy loss. Cytogenetic analysis may be performed on products of conception samples following the third and subsequent consecutive miscarriages or following the loss of a fetus with multiple structural abnormalities. Parental blood samples are accepted where: (1) testing of the products of conception sample shows an unbalanced structural fetal karyotype or (2) following the loss of a fetus with multiple congenital abnormalities or severe IUGR and material from the fetus or placenta is unavailable for cytogenetic testing.
Price & reporting times
|Test||Price (£ ex VAT)||TRT *|
|Routine postnatal blood sample||POA||28 cd|
|Fetal tissue or products of conception sample||POA||28 cd|
Test validation & quality assurance - information for users
Testing of fetal and products of conception samples may occasionally be complicated by maternal cell contamination. In these cases, it may not be possible to issue a result. QF-PCR may not detect mosaicism or structural rearrangements. Microarray analysis will not detected balanced rearrangements and may not detect mosaicism. Microarray analysis may identify incidental findings unrelated to the cause of pregnancy loss. This laboratory participates in the CEQAS quality assessment scheme for this test.
The most appropriate sample types are:
Please see our referral guidelines for more information.