Genomic science for healthcare: a unique collaboration
The Manchester Centre for Genomic Medicine (MCGM) unifies NHS services and The University of Manchester research and teaching, creating one of the leading centres for clinical genomics in Europe.
- MCGM is made up of 250 NHS doctors, genetic counsellors, informaticians, scientists and university research experts, working in a purpose-built space designed to promote interaction and creativity.
- We work with genomic scientists worldwide and are proud to have translated many of our research discoveries into new diagnostic tests and treatment trials to improve outcomes for our patients. We have trained many hundreds of genetic counsellors and scientists through internationally regarded academic and professional courses and workshops. Our informatic scientists have developed and promoted global networks for sharing clinical genomic data. We are proud to host major international networks to help provide quality-assured genomic services.
- Our focus is to make personalised medicine a reality for patients and families; using next generation genomic technologies to make a precise diagnosis, understand risks and make the best treatment and management decisions.
- Our practice is patient-centred; expert genetic counsellors help people understand and adjust to living with a genetic condition and our systems are designed to ensure that each generation can be made aware of the risks of an inherited disease in their family.
Clinical Genetic Service and the Willink Biochemical Genetics Unit
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We provide general clinics for populations around Manchester including Lancashire and parts of Cheshire and Cumbria. Our metabolic services extend from across the North of England to Dublin. MCGM hosts national specialised services for lysosomal storage disease, and neurofibromatosis types 1 and 2. Regional genetic services include paediatric metabolic conditions, prenatal assessement, dysmorphology, neuromuscular, neuropsychiatric, ophthalmic, cardiac and cancer genetics.
The Genomic Diagnostic Laboratory
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Our laboratory draws on the experience of 140 heathcare scientists. The fully accredited laboratory includes constitutional, oncology and biochemical genetics sections integrated with research, the bioinformatics team and clinical services. Our structure is designed to exploit the new generation of technologies offering a step-change in our ability to scan the genome for changes causing disease, monitor the progress of genetic conditions, choose therapies and measure their impact. In the last two years, building on a £1.3m investment by the Central Manchester University Hospitals NHS Foundation Trust and The University of Manchester in sequencing and bioinformatics, we have translated research findings into 10 new and validated genomic services. The new services complement a comprehensive base of diagnostics for a wide range of genetic disorders and molecular pathology indications. Our services attract referrals locally, nationally and internationally principally from the NHS but increasingly from research and clinical trials units and bio-industry.