Prof Dorothy Trump MA, MB, BChir, MRCP, MD

Secretary

Kim Tunicliffe
Tel: 0161 276 4150

Profile

Professor Dorothy Trump is a consultant in Clinical Genetics with a special interest in genetic eye disease and deafness. She qualified from Cambridge University in 1988 and trained in adult medicine before moving into genetics research in 1992. She developed an interest in genetic eye disease following her move to the Cambridge Department of Medical Genetics in 1995 and continued with her research interests whilst training in clinical genetics. Professor Trump was appointed to the Manchester Chair of Human Molecular Genetics in 2003. Professor Trump runs an active research group who investigate the molecular pathology of genetic disease in particular genetic eye disease. She uses molecular biological techniques to establish the functional basis of inherited eye disease with a particular emphasis on those affecting the inner retina. She is also part of the research team assessing neurodevelopmental phenotypes in NF. Professor Trump sits on the scientific advisory group of the British Society of Human Genetics and Academic subcommittee of the Clinical Genetics Society and is a Council Member of the Clinical Genetics Society.

Specialties

Deafness
Eye diseases

Publications

Jones RP, Ridley C, Jowitt TA, Wang MC, Howard M, Bobola N, Wang T, Bishop PN, Kielty CM, Baldock C, Lotery A, Trump D.

Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa.

Invest Ophthalmol Vis Sci 2010. (e-publ)
Gleghorn LJ, Trump D, Bulleid NJ.

Wild-type and missense mutants of retinoschisin co-assemble resulting in either intracellular retention or incorrect assembly of the functionally active octamer.

Biochem J. 2009;425:275-83.
Jones RP, Wang MC, Jowitt TA, Ridley C, Mellody KT, Howard M, Wang T, Bishop PN, Lotery AJ, Kielty CM, Baldock C, Trump D.

Fibulin 5 forms a compact dimer in physiological solutions.

J Biol Chem. 2009 Sep 18;284:25938-43
Choudhury R, McGovern A, Ridley C, Cain SA, Baldwin A, Wang MC, Guo C, Mironov A Jr, Drymoussi Z, Trump D, Shuttleworth A, Baldock C, Kielty CM.

Differential regulation of elastic fiber formation by fibulin-4 and -5.

J Biol Chem. 2009 Sep 4;284(36):24553-67.
Shi L, Jian K, Ko ML, Trump D, Ko GY.

Retinoschisin, a new binding partner for L-type voltage-gated calcium channels in the retina.

J Biol Chem. 2009 Feb 6;284:3966-75.
Zhang Y, Wang T, Ma A, Zhou X, Gui J, Wan H, Shi R, Huang C, Grace AA, Huang CL, Trump D, Zhang H, Zimmer T, Lei M.

Correlations between clinical and physiological consequences of the novel mutation R878C in a highly conserved pore residue in the cardiac Na+ channel.

Acta Physiol (Oxf). 2008 Dec;194(4):311-23.
Prattichizzo C, Macca M, Novelli V, Giorgio G, Barra A, Franco B; Oral-Facial-Digital Type I (OFDI) Collaborative Group.

Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients.

Hum Mutat. 2008 Oct;29:1237-46.
Ko ML, Liu Y, Shi L, Trump D, Ko GY.

Circadian regulation of retinoschisin in the chick retina.

Invest Ophthalmol Vis Sci. 2008 Apr;49:1615-21.
Hadfield KD, Newman WG, Bowers NL, Wallace A, Bolger C, Colley A, McCann E, Trump D, Prescott T, Evans DG.

Molecular characterisation of SMARCB1 and NF2 in familial and sporadic schwannomatosis.

J Med Genet. 2008 Jun;45:332-9.
Wang T, Baron M, Trump D.

An overview of Notch3 function in vascular smooth muscle cells.

Prog Biophys Mol Biol. 2008 Jan-Apr;96:499-509.